Heart failure: more clarity
Researchers at VUmc discovered what substance caused diastolic heart failure. By suppressing this particular substance, the heart muscle cells from patients may be made less rigid. This discovery provides future perspective for the development of a drug against a very common form of heart failure.
Previous research shows that the cardiomyocytes of heart patients are too stiff. Patients with diastolic heart failure have too much of the short, stiff variant of the protein titin. The researchers have written that the body’s enzyme PDE9 is the culprit here. Namely this enzyme works strongly by patients with this heart disease. PDE9 inhibits the body’s response to the protein supple. “If we can prevent the amount of PDE9 to increase, then hopefully we can make sure to relaxe the heart better.” Said co-author Dr. Nazha Hamdani, VUmc.